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4:3 Intermittent Fasting: A Better Weight Loss Strategy?

In recent years, intermittent fasting has ascended to prominence as a strategic nutritional approach for weight reduction. This method, colloquially referred to as time-restricted eating, encompasses a spectrum of variations that regulate the temporal boundaries of food intake. Among the most widely practiced protocols is the 16:8 method, which prescribes an 8-hour eating window followed by a 16-hour fasting period each day.
Other methodologies adopt a more pronounced caloric abstention, such as the 5:2 regimen, wherein individuals consume a standard diet for five days while significantly curbing caloric intake or fasting altogether for two non-consecutive days. Similarly, the 4:3 protocol expands upon this concept, advocating for unrestricted consumption on four days while enforcing rigorous dietary limitations on the remaining three.
A New Study Sheds Light on 4:3 Intermittent Fasting.
A groundbreaking study, recently featured in the Annals of Internal Medicine, delineates the comparative efficacy of 4:3 intermittent fasting versus conventional daily caloric restriction over a 12-month period. The findings suggest that intermittent fasting may confer a modestly superior weight loss advantage relative to sustained calorie monitoring, according to medicalnewstoday.com.
Investigating the Impact of Dietary Patterns on Weight Loss
A research team from the University of Colorado School of Medicine orchestrated a meticulously structured investigation involving 165 overweight or obese adults. Participants were randomly assigned to either the 4:3 intermittent fasting cohort or a continuous daily caloric restriction regimen for one year.
Individuals adhering to the intermittent fasting protocol were instructed to reduce caloric intake by 80% of their daily requirements on three non-consecutive days weekly while maintaining a balanced diet on the remaining four days. Conversely, those in the calorie restriction group were subjected to a uniform daily caloric reduction of 34.3%.
To facilitate adherence, all participants were granted complimentary gym memberships, access to group-based behavioral support, and education on macronutrient tracking and caloric regulation. Furthermore, they were encouraged to engage in a minimum of 300 minutes of physical activity per week.

4:3 Intermittent Fasting: A Better Weight Loss Strategy?
Evaluating the Outcomes: Weight Reduction and Metabolic Enhancements
Out of the initial 165 participants, 125 successfully completed the year-long study. The results revealed that individuals in the intermittent fasting group experienced an average weight loss of 7.6% of their total body weight, surpassing the 5% weight reduction observed in the calorie restriction cohort, as per medicalnewstoday.com.
Moreover, 58% of intermittent fasting participants managed to shed at least 5% of their initial weight, compared to 47% in the calorie restriction group. Beyond weight loss, intermittent fasting was associated with favorable cardiometabolic enhancements, including reductions in systolic blood pressure, LDL cholesterol, triglycerides, and fasting glucose levels.
Interestingly, individuals following the calorie restriction regimen exhibited improvements in diastolic blood pressure and HDL cholesterol levels. However, researchers noted that the precision of these cardiometabolic estimations varied, rendering some findings inconclusive.
Expert Insights: Assessing the Practicality of 4:3 Fasting
Dr. Victoria A. Catenacci, MD, lead researcher and associate professor at the University of Colorado Anschutz Medical Campus, emphasized the practicality of intermittent fasting as a viable alternative to conventional calorie restriction.
“Daily calorie restriction remains the most prevalent dietary weight loss strategy, yet its long-term adherence poses challenges for many individuals,” remarked Dr. Catenacci.
“Our findings indicate that the 4:3 intermittent fasting approach may be more sustainable over time, potentially yielding greater weight loss when coupled with behavioral support. As such, it merits consideration among evidence-based dietary interventions for those seeking effective weight management solutions.”
The Quest for an Optimal Fasting Regimen
Despite the promising results, experts urge further investigation to delineate the ideal intermittent fasting framework. Dr. Mir Ali, a board-certified bariatric surgeon and medical director at the MemorialCare Surgical Weight Loss Center, underscored the need for nuanced exploration.
“While the 4:3 fasting model demonstrated modest benefits, intermittent fasting’s efficacy has been substantiated across numerous studies. Additional research is imperative to refine the optimal fasting paradigm and ascertain its broader health implications.”
Dr. Monique Richard, registered dietitian nutritionist and founder of Nutrition-In-Sight, echoed similar sentiments, likening intermittent fasting to ‘metabolic confusion’—a phenomenon wherein caloric cycling intermittently disrupts metabolic homeostasis to enhance fat oxidation and energy expenditure, according to reports by medicalnewstoday.com.
“Though this study corroborates previous findings, the outcomes remain variable and contingent upon multiple individualized factors, including genetics, lifestyle habits, and psychological resilience.”
Choosing the Right Intermittent Fasting Schedule
For those contemplating the adoption of intermittent fasting—specifically the 4:3 regimen—several considerations must be weighed:

4:3 Intermittent Fasting: A Better Weight Loss Strategy?
Medication Interactions: Certain prescriptions, such as insulin or antihypertensives, may necessitate dietary consistency.
Psychological Tolerance: Individuals prone to hunger-induced irritability (“hangry” episodes) or headaches due to prolonged fasting should evaluate their capacity for extended caloric deprivation.
Social Feasibility: Commitment to a rigid fasting schedule may conflict with social engagements, celebratory gatherings, or familial meals, potentially fostering disordered eating behaviors.
Practical Strategies for Success
For optimal adherence, experts propose a gradual acclimatization strategy, such as:
Enlisting a support network to maintain motivation and accountability.
Incremental adaptation begins with a single 24-hour fasting cycle, progressively extending durations over time.
Maintaining nutritional discipline on non-fasting days, avoiding excessive caloric overcompensation.
Alternatively, the 4:3 method can be adapted by restricting caloric intake to 20% of daily requirements on fasting days, making the regimen more manageable, as per medicalnewstoday.com.
“A methodical, sustainable approach to dietary modifications often proves most effective,” advised Richard. “Collaborating with a Registered Dietitian Nutritionist (RDN) can provide personalized insights into nutrient requirements, ensuring the safety and efficacy of intermittent fasting.”
Final Thoughts
Intermittent fasting continues to captivate researchers and health enthusiasts alike, offering a flexible yet structured avenue for weight management. While the 4:3 fasting model exhibits promising advantages, its success ultimately hinges on individual adaptability, metabolic responses, and behavioral commitment. As research progresses, a deeper understanding of its long-term benefits and optimal implementation strategies will undoubtedly emerge, paving the way for more tailored dietary interventions.
NEWS
A Rising Storm: Dengue Fever’s Resurgence Amidst Climate Apathy

United States: Last week, a grave communiqué emerged from the Centers for Disease Control and Prevention (CDC), drawing urgent focus to the surge of dengue fever — a tormenting, sometimes lethal virus spread by mosquitoes, largely endemic to humid tropical and subtropical locales. According to the CDC’s account, roughly 3,500 American voyagers returned home in 2024 carrying the viral hitchhiker — an 84 percent escalation over the previous year. “This upward trajectory is forecast to persist,” the agency warned, identifying Florida, California, and New York as epicenters of impending proliferation.
Simultaneously, across the Atlantic, the United Kingdom Health Security Agency sounded a parallel alarm. Their figures indicated 900 travel-associated dengue diagnoses in 2024 — nearly 300 more than the prior annum. While both agencies delivered numerical snapshots of symptoms and rising cases, the UK’s advisory pierced deeper — naming the culprits: a heating planet, swelling tides, and intensifying storms. These environmental upheavals are scripting dengue’s meteoric ascent, according to the reports by grist.org.
Historically, the CDC has not shied away from acknowledging climate change’s role in disease transmission. However, since Donald Trump’s return to the presidency, the federal stance has changed course. Scientific lexicons such as “climate change” and “equity” have vanished from government websites. The agencies once tasked with decoding environmental threats have been systematically gutted — their data tools dismantled, their research pipelines throttled.
In a chilling turn, ProPublica revealed that the National Institutes of Health (NIH) — the globe’s most prolific patron of biomedical inquiry — will no longer extend funding for climate-linked health investigations. The future of existing grants now hangs in limbo. Days later, Health and Human Services Secretary Robert F. Kennedy Jr. declared a colossal retrenchment — 10,000 federal roles, including many at the CDC, are set to vanish. Ironically, this is the very agency born in 1946 to combat malaria, another mosquito-borne plague.

A Rising Storm: Dengue Fever’s Resurgence Amidst Climate Apathy
These sweeping edicts will hobble America’s readiness — and that of international collaborators reliant on NIH’s fiscal support — at the exact juncture when dengue is surging under climate duress. Stripping skilled personnel and dismantling institutions during a viral crescendo foretells grim outcomes as disease vectors like mosquitoes, fungi, and ticks migrate into previously untouched regions, as per grist.org.
“The pressure from vector-borne illness is swelling — and only trending upward,” remarked Scott O’Neill, founder of the World Mosquito Program, a global nonprofit combating mosquito-borne illness through biologically altered vectors. Brazil, long entrenched in dengue warfare, marked a record-shattering 10 million infections in 2024 — an immense spike from the 1.7 million in 2023.
The dengue virus is primarily ferried by Aedes aegypti and Aedes albopictus mosquitoes — creatures that thrive in climates increasingly sculpted by fossil-fueled warming. Although many infected experience no symptoms, nearly a quarter suffer fever, migraine, and debilitating joint agony. In rare cases, it morphs into severe illness — requiring hospitalization and sometimes ending in death.
The burden of lethal infections is a grim shadow of the total case count. For example, 2023 saw 6 million global infections and 6,000 fatalities. In 2024, those numbers doubled — 13 million afflicted and over 8,000 deceased.
There is no cure for dengue. Those in affluent countries often weather the illness with more support than those in under-resourced regions, where strained hospitals crumble under wave after wave of patients. Two vaccines exist — but both carry caveats concerning how long immunity lasts and their efficacy across demographics.
Between 2021 and the present, the NIH nurtured a bloom of climate-health scholarship — investing in projects probing how heat redraws mosquito maps, identifying outbreak triggers, and designing community resilience strategies post-flood or heatwave. These inquiries spanned from the American Southeast to nations like Brazil and Peru, where dengue is nearly perennial. NIH-backed researchers were edging toward breakthroughs, from smarter vaccines to genetically engineered mosquitoes incapable of transmitting the virus, according to the reports by grist.org.
“Viruses defy borders,” said one American entomologist and NIH grantee, who requested anonymity out of fear of retribution under the current administration. “If we abandon this line of inquiry, we surrender our future readiness.”

A Rising Storm: Dengue Fever’s Resurgence Amidst Climate Apathy
Dengue isn’t just a souvenir from overseas trips anymore — it’s sprouting roots within US borders. In early 2024, Puerto Rico rang the alarm, declaring a public health emergency amid a tidal wave of infections that crossed the epidemic threshold. Over half of those infected required hospitalization. A staggering 113 percent spike in cases compared to the same timeframe in 2024 has already been reported. California logged its first locally transmitted case last year. Florida noted 91 such infections in 2023 alone.
“This virus is now finding purchase in American zip codes that never before bore its sting,” noted Dr. Renzo Guinto, head of the Planetary Health Initiative at Duke-NUS in Singapore. “Yet without funding, without infrastructure, without partnerships, how can the US remain part of a global defense?”
Alternate funding sources — think Gates Foundation or the Wellcome Trust — do exist. However, their allocations pale next to the USD 40 million NIH annually devoted to climate-health fusion research pre-Trump. Now, scientists will be left clawing for diminishing grants — breeding scarcity and stifling discovery. “We’ll see a steep drop in innovation,” the same entomologist predicted. “And the American public will be worse off for it.”
As dengue fans out across its familiar tropics and inches deeper into temperate nations unaccustomed to its presence, the global need for smarter, faster, broader defense tools becomes unmistakable. But while the world girds itself, the US appears to be disarming, as per reports by grist.org.
“We’re standing at the crossroads,” said O’Neill. “This is the moment to galvanize invention and mobilize science — not muzzle it under ideology.”
NEWS
Texas Grapples with Surging Measles Outbreak, Tally Climbs Past 600

United States: In a harrowing turn of public health events, the state of Texas has now documented 624 confirmed instances of measles since late January, as revealed by the Texas Department of State Health Services. This tally reflects an uptick of 27 fresh cases since April 18, underscoring the virus’s swift infiltration, particularly throughout western counties.
A Childhood Menace Reawakens
The recent wave has proven especially unforgiving among the young. A staggering 186 cases involve children aged four and under, while another 236 affect individuals aged 5 to 17. Tragically, the virus has claimed the lives of two unvaccinated children, one being an 8-year-old girl—both reportedly free of prior health complications, according to USA Today.
Hospitals Strained Amid Climb in Admissions
So far, 64 patients have been hospitalized, adding strain to already taxed medical facilities. Although health authorities report that less than 2 percent of patients are currently contagious, the virus’s perilous incubation—four days before and after the rash appears—continues to sow anxiety in affected communities.
Outbreak’s Epicenter: The Western Counties
The virus’s fury is concentrated across ten counties, including Cochran, Lynn, Terry, and notably Gaines County, which alone accounts for 386 of the total cases, an escalation from 371 just days prior.
🇺🇸TEXAS MEASLES OUTBREAK: 624 CASES AND COUNTING — MOST SKIPPED THE SHOT
Texas just hit 624 confirmed measles cases — that’s 27 more than last week.
Gaines County is the epicenter with 386 cases (yes, over 60% of the state’s total).
Terry (54) and Lubbock (47) are also racking… https://t.co/Idk4fkdFHi pic.twitter.com/2EwuT2B9RU
— Mario Nawfal (@MarioNawfal) April 22, 2025
Contagion Crosses Borders
Neighboring New Mexico has also recorded 65 cases, with Lea County, adjacent to Gaines, being its epicenter. Officials anticipate more infections will emerge, given the virus’s contagious prowess.
Federal Agencies Step In
In response, the Centers for Disease Control and Prevention (CDC) dispatched 22 professionals to Texas between March and mid-April to assist with containment strategies and deliver field expertise.
A National Wake-Up Call
This spike pushes the nation toward a dangerous milestone: 800 confirmed measles cases across 24 states as of April 18, well surpassing last year’s total of 285. Ten official outbreaks have been tallied in 2025 so far, defined by three or more linked cases, as per USA Today.
Young Lives at Heightened Risk
Of these 800 infections, 31 percent afflict children under 5, and 38% are among those aged 5 to 19. The CDC states that 96 percent of all cases involve unvaccinated individuals or those with unknown vaccine status—a damning reflection of public hesitancy and misinformation.

Texas Grapples with Surging Measles Outbreak, Tally Climbs Past 600
The Underrated Threat
Measles is not just a rash and fever—it’s a ruthless adversary. Complications span from pneumonia and deafness to brain inflammation and fatalities, particularly among the vulnerable: infants, pregnant women, and the unvaccinated.
Immunization: The Imperative Shield
The antidote to this scourge remains steadfast: the MMR vaccine, which offers 97 percent protection when fully administered. Typically, children receive the first dose between 12 to 15 months and a booster at 4 to 6 years, as per USA Today.
Meanwhile, those born before 1957 are considered immune, having likely endured natural infection during their formative years.
A Clarion Call for Action
As measles tightens its grip and brushes against the US’s measles elimination status, the moment demands more than awareness—it calls for bold collective action, revitalized trust in science, and an uncompromising return to foundational public health safeguards.
NEWS
Dangerous Resurgence: Whooping Cough Threatens Infants, Experts Warn

As whooping cough starts to make a strong comeback, health experts are urging everyone to check if they’re up to date on their Tdap booster right away.
Pertussis—commonly termed whooping cough—is a ferociously contagious respiratory affliction marked by spasmodic bouts of hacking coughs. Especially perilous for the youngest among us, nearly a third of infants under 12 months old require hospitalization upon infection, per the Centers for Disease Control & Prevention (CDC).
Yet this disease remains eminently avertible. Immunization remains the preeminent bulwark against pertussis. The DTaP and Tdap inoculations offer considerable protection—but only with diligent adherence to booster schedules. Here’s the essential intel medical experts are keen for the public to absorb, according to USA Today.
DTaP vs Tdap: The Immunological Distinction
Both DTaP and Tdap serve as multi-threat vaccines, conferring resistance against tetanus, diphtheria, and pertussis. DTaP is engineered for pediatric patients—infants and toddlers—while Tdap is formulated for individuals aged seven and older, notes Dr. Peter Chin-Hong, a medicine professor and infectious disease connoisseur at UCSF Health.
The DTaP formulation is robust—full-strength dosages of all three antigens. In contrast, Tdap is a tempered variant: a singular full tetanus dose, with reduced measures of diphtheria and pertussis antigens. Today’s pertussis inoculations utilize acellular fragments—deactivated bacterial derivatives from Bordetella pertussis, per CDC mandates.

Dangerous Resurgence: Whooping Cough Threatens Infants, Experts Warn
“These immunizations function akin to a seat belt—not infallible, but profoundly preventative,” stated Dr. Matthew Harris, pediatric emergency physician and Northwell Health’s clinical preparedness director. Though not impervious, vaccinated individuals who contract pertussis typically encounter diminished symptom severity.
Childhood Protocol: Timing of DTaP Injections
Contrary to common assumptions, adults aren’t the primary casualties of this tenacious disease—children are. Its virulence among the young can provoke dire outcomes, including respiratory arrest and pulmonary infections, warns Dr. Chin-Hong.
The CDC’s pediatric immunization schedule advises a quintet of DTaP doses before age seven, precisely at:
– 2 months
– 4 months
– 6 months
– 15 to 18 months
– 4 to 6 years
This early-life sequence forges an immunological barrier during the most vulnerable years.
Duration and Longevity of Tdap Protection
Adolescents are slated to receive their initial Tdap jab between ages 11 and 12. For those unvaccinated in childhood, Tdap acts as the foundational dose, as per USA Today.
Unlike the enduring protection offered by the MMR vaccine (notably, 97% measles immunity post-second dose), Tdap immunity isn’t lifelong. Among tetanus, diphtheria, and pertussis, it’s pertussis immunity that fades most swiftly, affirms Dr. Chin-Hong.
Hence, the CDC prescribes a decennial Tdap or Td booster (the latter excludes pertussis and diphtheria). This ensures immunity remains potent over time.

Dangerous Resurgence: Whooping Cough Threatens Infants, Experts Warn
Suffered a puncture wound or scald? You might necessitate an urgent Tdap, DTaP, or Td dose—especially if your last immunization has aged. Physicians weigh the injury’s depth, your medical history, and the recency of prior shots, notes Dr. Harris.
Shielding the Youngest: Tdap & Infant Proximity
Absolutely—proximity to infants demands an updated Tdap shot, regardless of prior inoculation dates. Neonates under eight weeks remain immunologically barren, unable to receive their own DTaP, highlights Dr. Chin-Hong.
Pregnant individuals are particularly urged by the American College of Obstetrics and Gynecology to receive Tdap in the third trimester (weeks 27–36). This maternal dosage facilitates the transfer of protective antibodies in utero, arming the newborn with vital immunological defenses, according to reports by USA Today.
CDC data suggests this maternal immunization slashes newborn pertussis cases by approximately 78 percent.
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